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What is hormesis?
Hormesis is a concept borrowed from toxicology that explains why certain things that are toxic in high quantities can be beneficial at low doses. What is hormesis? Hormesis is a term that comes from toxicology and refers to the paradoxical beneficial effect experienced by an organism exposed to a low dose of a substance or environmental factor which is toxic at higher doses (1). This is called “biphasic dose response” in scientific lingo, often described as U-shaped or J-shape curve (1, 2, 3). It is believed that the role of hormesis is to restore homeostasis, i.e. a balanced state, when it has been disrupted. This allows organisms to adapt to…
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Book review: Lifespan (David Sinclair)
Lifespan: Why We Age – and Why We Don’t Have To is a remarkable book by Harvard professor David Sinclair. Sinclair postulates that aging is a disease and can be “cured” by activating the right pathways. The author David Sinclair is a Sydney-born biologist who earned his Bachelor of Science and PhD at the University of New South Wales (NSW). He is now a professor in the Department of Genetics and the co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He also has a lab in his alma mater UNSW. His work focuses on aging and how to slow it down or…
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Fruit and vegetable intake: Guidelines vs reality
The Australian Dietary Guidelines recommend an average minimum daily intake of 5 serves of vegetables (including legumes) and 2 serves of fruit to prevent chronic disease. Nutrients in fruits and vegetables Most fruits, vegetables and legumes are good source of carbohydrate (sugar and/or starch) and fibre. They also water and contain micronutrients, such as vitamins, minerals and phytochemicals. Most are low in fat with few exceptions (olives, avocados, coconuts). Legumes are a decent source of protein and some contain non-haem iron, which is less bioavailable than haem iron from animal sources. Legumes also contain phytates which act as antioxidants but bind to minerals, affecting their absorption. Cooking and storing methods…
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Book review: The Longevity Diet (Prof Valter Longo)
The Longevity Diet is one of these few diet books worth reading. It was written by Prof Valter Longo, one of the leading scientists in the field of longevity. Prof Longo has been experimenting with fasting-mimicking protocols in order to extend life and vitality. One of the coolest facts about Prof Longo I learned from his book is that he wanted to become a rock star and that’s why he travelled from his home town in Italy to the US. He was on his way through a jazz composition major when he decided to change gears and pursue an interest that had been dormant in his mind: to study the…
